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added: Wed, 28th September 2005 | 270 views | 0x in favourites
feed url: http://www.signaling-gateway.org/update/rss.rdf
Nature Signaling Update, Nature Publishng Group
A rational design-based approach to developing targeted therapeutics has generated a small-molecule inhibitor that blocks both PI(3)K and tyrosine kinase activity.
Knocking out the p53 homolog TAp73 has revealed a role for the protein in tumor suppression and the maintenance of genomic integrity.
Two studies reveal an important function for amyloid-beta (Abeta) peptides in the pathogenesis of Alzheimer's disease and suggest a novel therapeutic approach to tackle Abeta's deleterious effects.
A directed evolution approach has been successful in designing G protein-coupled receptors (GPCRs) with greater stability and enhanced expression.
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