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added: Wed, 28th September 2005 | 1210 views | 1x in favourites
feed url: http://www.fightaging.org/index.xml
Reports from the front line in the fight against aging. The science of healthy life extension. Activism and advocacy for longer, healthier lives.
The more time you spend thinking about aging, longevity science, and a future in which aging can be repaired, the further you move away from the mindset shared by most people in the world. At times it can be a challenge to recall that, yes, you lived in a "pro-aging trance" back in the day, accepting that growing old and dying was just the way of things. It's a part of the very human tendency to see the world as it is, continuing forever: at some level, we're hardwired to reject all prospects for change as being somewhat ridiculous. So we grow up in the world that is, and comparatively few people spend much time looking beyond that to the world that could be. Anyway, this line of thinking is prompted by an interesting post over at In Search of Enlightenment: Those who have read some of my academic work, or past entries on this blog, will know I am an advocate of longevity science. I am very interested in hearing the arguments and reactions people have to the aspiration to slow human aging, for I myself shared some of these reservations when I first began thinking about these issues....
As I've noted in the past, it's essential to keep an eye on progress in infrastructure in science and research. When costs are lowered and easy of use increases, more people join the research community, and those already achieve existing goals more rapidly. New goals, previously too costly to consider, become attainable. Cost of infrastructure is the foundation upon which a research community takes form and makes progress. Cost isn't just a matter of dollars, of course, though it all boils down to dollars and time in the end. You have to consider the skills of potential researchers - is the technique too hard for most? Also the equipment needed for a given strategy: do many laboratories already have it in place, and thus have no need to invest money before research can commence? Improvement can be as much a matter of making new strategies work for existing staff and equipment as inventing a new and cheaper methodology. I noticed an article today that gives a very good idea of the level of benefit brought to the regenerative medicine community by the development of induced pluripotent stem (iPS) cells. To refresh your memory as to what these are: A pluripotent...
The Immortality Institute's Folding@Home prize contest enters its third quarter: The 2nd quarter of the F@H prize competition came to a close September 30th and it was been another blowout quarter in terms of team success. During the 2nd quarter the Longevity Meme team rose from position 167 to 124 (as of Sept 24th) while PPD output increased 200% (up to an average of 160,000). The 3rd quarter competition is now in swing (all competitor’s scores were reset to zero October 1st) and even more prize money is up for grabs due to generous support from the Life Extension Foundation. Not only has the prize amount for the top twelve competitors increased, a 13th prize has been added – to be randomly awarded to one folder who is outside of the top 12. To top it all off, the Life Extension Foundation has offered a free 6 month LEF membership to all of the F@H prize registrants Competitors are earning their prizes by contributing unused processor cycles from their computers to the Stanford Folding@Home project. The process of protein folding, while critical and fundamental to virtually all of biology, in many ways remains a mystery. Moreover, when proteins do not...
Research in recent years has made it clear that the composition of the membranes in your cells - the relative proportions of proteins and amino acids that make up their structure - has a lot to do with how long you live. When comparing longevity between species, at least. This is the membrane pacemaker theory of longevity: The membrane pacemaker hypothesis predicts that long-living species will have more peroxidation-resistant membrane lipids than shorter living species. Mitochondria, the power plants of your cells, generate damaging reactive oxygen species (ROS) in the course of their operation: ROS will race off to damage the first thing they can find by reacting with it, such as a cell membrane. Mitochondria themselves have membranes, and are first in line to be damaged by the ROS they generate. Eventually damage accumulates and cascades to change the surrounding cellular environment very much for the worse. This process is an important root cause of degenerative aging. This is why those species more resistant to the damaging effects of reactive oxygen species live longer than their peers. A good example is the naked mole rat, which lives eight times longer than similarly sized rodent species. With this theme in...
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